SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02223

Signal sequence   MKLLMVLMLAALLLHCYA

Length  18

Organism  Homo sapiens (Human)

UniProt ID  O75556,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02223.cif

Structure  SPKB02223.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2047.70784

Aliphatic index  184.4444444

Isoelectric point  8.530526343

Charge (pH=7)   1.025773226

Topological polar surface area  632.95

Aromaticity  0.055555556

Average rotatable bonds  3.777777778

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  26

X logP energy  1.9105

Hydropathy 



Literature Information


Title  Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification.

DOI  10.1021/acs.jproteome.5b00179,

Publication Year  2015

PubMed ID  25946035,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.