SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02215

Signal sequence   MIRNWLTIFILFPLKLVEKCES

Length  22

Organism  Homo sapiens (Human)

UniProt ID  O60931,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8DKE,

Predicted Structure ID  SPKB02215.cif

Structure  SPKB02215.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2694.33194

Aliphatic index  137.2727273

Isoelectric point  8.540441717

Charge (pH=7)   0.93896645

Topological polar surface area  953.51

Aromaticity  0.136363636

Average rotatable bonds  4.045454545

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  33

X logP energy  -1.54433

Hydropathy 



Literature Information


Title  Impact of Cystinosin Glycosylation on Protein Stability by Differential Dynamic Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC).

DOI  10.1074/mcp.M116.063867,

Publication Year  2017

PubMed ID  28082515,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.