SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02209

Signal sequence   MRTGWATPRRPAGLLMLLFWFFDLAEP

Length  27

Organism  Homo sapiens (Human)

UniProt ID  O60449,

Motif  1..27



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7JPU,

Predicted Structure ID  SPKB02209.cif

Structure  SPKB02209.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3193.82074

Aliphatic index  83.33333333

Isoelectric point  10.30863985

Charge (pH=7)   1.000195972

Topological polar surface area  1125.89

Aromaticity  0.185185185

Average rotatable bonds  3.518518519

Number of hydrogen bond donors  40

Number of hydrogen bond acceptors  37

X logP energy  -3.35209

Hydropathy 



Literature Information


Title  The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family.

DOI  10.1002/(SICI)1521-4141(199812)28:12<4071::AID-IMMU4071>3.0.CO;2-O,

Publication Year  1998

PubMed ID  9862343,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.