SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02206

Signal sequence   MNLPSTKVPWAAVTLLLLLLLPPALLSLGVDA

Length  32

Organism  Rattus norvegicus (Rat)

UniProt ID  O55232,

Motif  1..32



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02206.cif

Structure  SPKB02206.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3341.13924

Aliphatic index  173.75

Isoelectric point  6.337367167

Charge (pH=7)   -0.00186425

Topological polar surface area  1133.38

Aromaticity  0.03125

Average rotatable bonds  3.15625

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  41

X logP energy  -3.6596

Hydropathy 



Literature Information


Title  Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

DOI  10.1016/s0092-8674(00)80949-6,

Publication Year  1998

PubMed ID  9491897,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.