SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02194

Signal sequence   MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQA

Length  35

Organism  Homo sapiens (Human)

UniProt ID  O43278,

Motif  1..35



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02194.cif

Structure  SPKB02194.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3591.35504

Aliphatic index  112

Isoelectric point  12.19926402

Charge (pH=7)   2.93599965

Topological polar surface area  1374.71

Aromaticity  0.028571429

Average rotatable bonds  3.171428571

Number of hydrogen bond donors  49

Number of hydrogen bond acceptors  47

X logP energy  -11.92469

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.