SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02187

Signal sequence   MQRAMLLGLLGAAALAAVIS

Length  20

Organism  Rattus norvegicus (Rat)

UniProt ID  O35314,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02187.cif

Structure  SPKB02187.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1970.46244

Aliphatic index  161.5

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  741.44

Aromaticity  0

Average rotatable bonds  3.3

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  26

X logP energy  -5.04843

Hydropathy 



Literature Information


Title  The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region.

DOI  10.1002/j.1460-2075.1987.tb02355.x,

Publication Year  1987

PubMed ID  3608978,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.