SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02178

Signal sequence   MRQTLPCIYFWGGLLPFGMLCAS

Length  23

Organism  Homo sapiens (Human)

UniProt ID  O15455,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7C76,

Predicted Structure ID  SPKB02178.cif

Structure  SPKB02178.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2605.18684

Aliphatic index  89.13043478

Isoelectric point  8.222829177

Charge (pH=7)   0.873181142

Topological polar surface area  867.41

Aromaticity  0.173913043

Average rotatable bonds  3.391304348

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  33

X logP energy  -3.35373

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.