SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02176

Signal sequence   MARIPKTLKFVVVIVAVLLPVLAYS

Length  25

Organism  Homo sapiens (Human)

UniProt ID  O14798,

Motif  1..25



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02176.cif

Structure  SPKB02176.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2741.50124

Aliphatic index  175.2

Isoelectric point  10.90180955

Charge (pH=7)   2.996540506

Topological polar surface area  918.77

Aromaticity  0.08

Average rotatable bonds  3.44

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  33

X logP energy  -0.84333

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.