SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02175

Signal sequence   MEGAALLRVSVLCIWMSALFLGVGVRA

Length  27

Organism  Homo sapiens (Human)

UniProt ID  O14791,

Motif  1..27



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02175.cif

Structure  SPKB02175.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2863.53364

Aliphatic index  144.4444444

Isoelectric point  8.549845238

Charge (pH=7)   0.937778084

Topological polar surface area  1037.27

Aromaticity  0.074074074

Average rotatable bonds  3.444444444

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  36

X logP energy  -5.34386

Hydropathy 



Literature Information


Title  Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L.

DOI  10.1074/jbc.272.41.25576,

Publication Year  1997

PubMed ID  9325276,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.