General Information
SPKB ID SPKB02173
Signal sequence MGLQACLLGLFALILSGKC
Length 19
Organism Homo sapiens (Human)
UniProt ID O14773,
Motif 1..19
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID 3EE6,
Predicted Structure ID SPKB02173.cif
Physicochemical Information
Molecular weight 1951.47414
Aliphatic index 154.2105263
Isoelectric point 8.229691165
Charge (pH=7) 0.873739834
Topological polar surface area 676.46
Aromaticity 0.052631579
Average rotatable bonds 3.473684211
Number of hydrogen bond donors 25
Number of hydrogen bond acceptors 26
X logP energy -3.3764
Hydropathy 
Literature Information
Title The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH.
Publication Year 2001
PubMed ID 11054422,
Patent ID NA,
