SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02172

Signal sequence   MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESAL

Length  55

Organism  Homo sapiens (Human)

UniProt ID  O14763,

Motif  1..55



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02172.cif

Structure  SPKB02172.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  5665.61264

Aliphatic index  92.36363636

Isoelectric point  12.38783597

Charge (pH=7)   6.093605512

Topological polar surface area  2418.09

Aromaticity  0

Average rotatable bonds  3.327272727

Number of hydrogen bond donors  84

Number of hydrogen bond acceptors  77

X logP energy  -28.00701

Hydropathy 



Literature Information


Title  TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

DOI  10.1093/emboj/16.17.5386,

Publication Year  1997

PubMed ID  9311998,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.