SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02158

Signal sequence   MKPLVKLFLLFCLVGIVLS

Length  19

Organism  Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

UniProt ID  O01949,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02158.cif

Structure  SPKB02158.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2133.80844

Aliphatic index  189.4736842

Isoelectric point  9.676237541

Charge (pH=7)   1.935419516

Topological polar surface area  650.6

Aromaticity  0.105263158

Average rotatable bonds  3.684210526

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  25

X logP energy  1.9716

Hydropathy 



Literature Information


Title  Aegyptin, a novel mosquito salivary gland protein, specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin alpha2beta1, and von Willebrand factor.

DOI  10.1074/jbc.M705669200,

Publication Year  2007

PubMed ID  17650501,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.