SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02147

Signal sequence   MKVLRCLVCSFYIIVSLITTMTIG

Length  24

Organism  Rhipicephalus appendiculatus (Brown ear tick)

UniProt ID  M1MR49,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02147.cif

Structure  SPKB02147.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2705.42944

Aliphatic index  150

Isoelectric point  8.798094803

Charge (pH=7)   1.872886108

Topological polar surface area  941.92

Aromaticity  0.083333333

Average rotatable bonds  3.708333333

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  37

X logP energy  -4.45313

Hydropathy 



Literature Information


Title  Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses.

DOI  10.1371/journal.ppat.1003450,

Publication Year  2013

PubMed ID  23825947,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.