SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02140

Signal sequence   MEGMALYLVAALLIGFPGSSHG

Length  22

Organism  Ophiophagus hannah (King cobra) (Naja hannah)

UniProt ID  I2C090,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02140.cif

Structure  SPKB02140.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2234.65634

Aliphatic index  115.4545455

Isoelectric point  5.363445804

Charge (pH=7)   -0.910181901

Topological polar surface area  792.3

Aromaticity  0.090909091

Average rotatable bonds  3.181818182

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  30

X logP energy  -4.9305

Hydropathy 



Literature Information


Title  Molecular cloning and characterization of a complement-depleting factor from king cobra, Ophiophagus hannah.

DOI  10.1016/j.toxicon.2012.04.344,

Publication Year  2012

PubMed ID  22561424,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.