SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02125

Signal sequence   MAGKLGVLLLALVLSLAQPASA

Length  22

Organism  Bos taurus (Bovine)

UniProt ID  F1N5C8,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02125.cif

Structure  SPKB02125.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2136.66454

Aliphatic index  173.1818182

Isoelectric point  9.700002532

Charge (pH=7)   0.997689266

Topological polar surface area  775.2

Aromaticity  0

Average rotatable bonds  3.181818182

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  28

X logP energy  -4.7855

Hydropathy 



Literature Information


Title  Bovine brain myelin glycerophosphocholine choline phosphodiesterase is an alkaline lysosphingomyelinase of the eNPP-family, regulated by lysosomal sorting.

DOI  10.1007/s11064-012-0921-z,

Publication Year  2013

PubMed ID  23161088,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.