SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02107

Signal sequence   MKRFLLFISILMMIGTIVVG

Length  20

Organism  Tityus fasciolatus (Central Brazilian scorpion)

UniProt ID  C0HJM9,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02107.cif

Structure  SPKB02107.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2282.97594

Aliphatic index  165.5

Isoelectric point  11.65177567

Charge (pH=7)   1.997685954

Topological polar surface area  744.6

Aromaticity  0.1

Average rotatable bonds  3.9

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  28

X logP energy  0.01707

Hydropathy 



Literature Information


Title  The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.

DOI  10.1371/journal.pone.0128578,

Publication Year  2015

PubMed ID  26083731,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.