SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02071

Signal sequence   MKLLAPVLWAMAALGVTWLVAVDS

Length  24

Organism  Conus purpurascens (Purple cone)

UniProt ID  A0A5C2A2T2,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02071.cif

Structure  SPKB02071.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2556.16284

Aliphatic index  150.4166667

Isoelectric point  6.337367167

Charge (pH=7)   -0.00186425

Topological polar surface area  859.19

Aromaticity  0.083333333

Average rotatable bonds  3.25

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -1.4287

Hydropathy 



Literature Information


Title  Conodipine-P1-3, the First Phospholipases A(2) Characterized from Injected Cone Snail Venom.

DOI  10.1074/mcp.RA118.000972,

Publication Year  2019

PubMed ID  30765458,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.