SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02061

Signal sequence   MEIKYLLTVFLVLLIVSDHCQA

Length  22

Organism  Androctonus crassicauda (Arabian fat-tailed scorpion)

UniProt ID  A0A0A1I6E7,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02061.cif

Structure  SPKB02061.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2549.12494

Aliphatic index  168.1818182

Isoelectric point  5.451763262

Charge (pH=7)   -0.972005167

Topological polar surface area  907.5

Aromaticity  0.090909091

Average rotatable bonds  3.818181818

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  33

X logP energy  -2.1635

Hydropathy 



Literature Information


Title  Cationicity-enhanced analogues of the antimicrobial peptides, AcrAP1 and AcrAP2, from the venom of the scorpion, Androctonus crassicauda, display potent growth modulation effects on human cancer cell lines.

DOI  10.7150/ijbs.9859,

Publication Year  2014

PubMed ID  25332684,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.