SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02045

Signal sequence   APVSTETDIDDLPISVPEEALIGFIDLTGDEVSLLPVNNGTHTGILFLNTTIAEAAFADKDDLEKR

Length  66

Organism  Artificial

UniProt ID  NA,

Motif  1..66



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02045.cif

Structure  SPKB02045.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7039.81454

Aliphatic index  109.3939394

Isoelectric point  3.652534076

Charge (pH=7)   -10.89747738

Topological polar surface area  2916.05

Aromaticity  0.045454545

Average rotatable bonds  3.46969697

Number of hydrogen bond donors  96

Number of hydrogen bond acceptors  98

X logP energy  -28.68023

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.