SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02039

Signal sequence   EARDSWASPGGQSTRADDAINVAGTGGSILRPAKFSTLDSRRSKRSSE

Length  48

Organism  Artificial

UniProt ID  NA,

Motif  1..48



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02039.cif

Structure  SPKB02039.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  5050.45314

Aliphatic index  51.04166667

Isoelectric point  10.72103115

Charge (pH=7)   2.002710546

Topological polar surface area  2405.41

Aromaticity  0.041666667

Average rotatable bonds  3.520833333

Number of hydrogen bond donors  88

Number of hydrogen bond acceptors  77

X logP energy  -37.04018

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.