SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02026

Signal sequence   APVSTETDIDDLPISVPEEALIGFIDLTGDEVSLLPVNNGTHTGILFLNTTIAEAAFADKDDLE

Length  64

Organism  Artificial

UniProt ID  NA,

Motif  1..64



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02026.cif

Structure  SPKB02026.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  6755.45294

Aliphatic index  112.8125

Isoelectric point  3.345319491

Charge (pH=7)   -12.89717903

Topological polar surface area  2769.93

Aromaticity  0.046875

Average rotatable bonds  3.390625

Number of hydrogen bond donors  90

Number of hydrogen bond acceptors  94

X logP energy  -27.0421

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.