SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02009

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLDKREEGEP

Length  71

Organism  Artificial

UniProt ID  NA,

Motif  1..71



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02009.cif

Structure  SPKB02009.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7484.12934

Aliphatic index  86.61971831

Isoelectric point  3.550924073

Charge (pH=7)   -10.98525097

Topological polar surface area  3222.83

Aromaticity  0.056338028

Average rotatable bonds  3.436619718

Number of hydrogen bond donors  106

Number of hydrogen bond acceptors  108

X logP energy  -37.95973

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.