SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02008

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLREEGEPK

Length  70

Organism  Artificial

UniProt ID  NA,

Motif  1..70



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6KRL,

Predicted Structure ID  SPKB02008.cif

Structure  SPKB02008.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7369.04074

Aliphatic index  87.85714286

Isoelectric point  3.600354195

Charge (pH=7)   -9.985697452

Topological polar surface area  3156.43

Aromaticity  0.057142857

Average rotatable bonds  3.428571429

Number of hydrogen bond donors  104

Number of hydrogen bond acceptors  106

X logP energy  -36.91923

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.