SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01994

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLDKEEEPK

Length  70

Organism  Artificial

UniProt ID  NA,

Motif  1..70



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01994.cif

Structure  SPKB01994.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7399.06404

Aliphatic index  87.85714286

Isoelectric point  3.550924066

Charge (pH=7)   -10.98554269

Topological polar surface area  3157.85

Aromaticity  0.057142857

Average rotatable bonds  3.457142857

Number of hydrogen bond donors  103

Number of hydrogen bond acceptors  107

X logP energy  -36.2102

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.