SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01986

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLDKREEPK

Length  70

Organism  Artificial

UniProt ID  NA,

Motif  1..70



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01986.cif

Structure  SPKB01986.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7426.13604

Aliphatic index  87.85714286

Isoelectric point  3.732315321

Charge (pH=7)   -8.987321125

Topological polar surface area  3182.45

Aromaticity  0.057142857

Average rotatable bonds  3.471428571

Number of hydrogen bond donors  105

Number of hydrogen bond acceptors  107

X logP energy  -36.81173

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.