SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01918

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLRGEPK

Length  68

Organism  Artificial

UniProt ID  NA,

Motif  1..68



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6KRL,

Predicted Structure ID  SPKB01918.cif

Structure  SPKB01918.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7110.80974

Aliphatic index  90.44117647

Isoelectric point  3.683666447

Charge (pH=7)   -7.989247698

Topological polar surface area  3023.63

Aromaticity  0.058823529

Average rotatable bonds  3.382352941

Number of hydrogen bond donors  100

Number of hydrogen bond acceptors  102

X logP energy  -35.61843

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.