SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01776

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLGPK

Length  66

Organism  Artificial

UniProt ID  NA,

Motif  1..66



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6KRL,

Predicted Structure ID  SPKB01776.cif

Structure  SPKB01776.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  6825.50674

Aliphatic index  93.18181818

Isoelectric point  3.544784796

Charge (pH=7)   -7.991019509

Topological polar surface area  2866.23

Aromaticity  0.060606061

Average rotatable bonds  3.318181818

Number of hydrogen bond donors  94

Number of hydrogen bond acceptors  98

X logP energy  -33.7161

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.