SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01753

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLKEK

Length  66

Organism  Artificial

UniProt ID  NA,

Motif  1..66



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01753.cif

Structure  SPKB01753.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  6928.62774

Aliphatic index  93.18181818

Isoelectric point  3.683666434

Charge (pH=7)   -7.989539421

Topological polar surface area  2938.34

Aromaticity  0.060606061

Average rotatable bonds  3.439393939

Number of hydrogen bond donors  97

Number of hydrogen bond acceptors  100

X logP energy  -33.8599

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.