SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01718

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLRG

Length  65

Organism  Artificial

UniProt ID  NA,

Motif  1..65



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6KRL,

Predicted Structure ID  SPKB01718.cif

Structure  SPKB01718.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  6756.40344

Aliphatic index  94.61538462

Isoelectric point  3.544784802

Charge (pH=7)   -7.990727787

Topological polar surface area  2881.8

Aromaticity  0.061538462

Average rotatable bonds  3.353846154

Number of hydrogen bond donors  96

Number of hydrogen bond acceptors  97

X logP energy  -34.57283

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.