SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01705

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLG

Length  64

Organism  Artificial

UniProt ID  NA,

Motif  1..64



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6KRL,

Predicted Structure ID  SPKB01705.cif

Structure  SPKB01705.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  6600.21594

Aliphatic index  96.09375

Isoelectric point  3.311571952

Charge (pH=7)   -8.990724476

Topological polar surface area  2790.8

Aromaticity  0.0625

Average rotatable bonds  3.3125

Number of hydrogen bond donors  92

Number of hydrogen bond acceptors  95

X logP energy  -33.3209

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.