SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01703

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLR

Length  64

Organism  Artificial

UniProt ID  NA,

Motif  1..64



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6KRL,

Predicted Structure ID  SPKB01703.cif

Structure  SPKB01703.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  6699.35154

Aliphatic index  96.09375

Isoelectric point  3.544784802

Charge (pH=7)   -7.990727787

Topological polar surface area  2852.7

Aromaticity  0.0625

Average rotatable bonds  3.375

Number of hydrogen bond donors  95

Number of hydrogen bond acceptors  96

X logP energy  -33.68903

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.