SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01700

Signal sequence   APVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSL

Length  63

Organism  Artificial

UniProt ID  NA,

Motif  1..63



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6KRL,

Predicted Structure ID  SPKB01700.cif

Structure  SPKB01700.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  6543.16404

Aliphatic index  97.61904762

Isoelectric point  3.311571952

Charge (pH=7)   -8.990724476

Topological polar surface area  2761.7

Aromaticity  0.063492063

Average rotatable bonds  3.333333333

Number of hydrogen bond donors  91

Number of hydrogen bond acceptors  94

X logP energy  -32.4371

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.