SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01697

Signal sequence   EPWSTLTVTRSTYDEITDTDYNSTGIAVNPYTVSASRHKRDV

Length  42

Organism  Artificial

UniProt ID  NA,

Motif  1..42



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01697.cif

Structure  SPKB01697.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4748.11044

Aliphatic index  60.23809524

Isoelectric point  4.703274118

Charge (pH=7)   -1.908626638

Topological polar surface area  2128.69

Aromaticity  0.095238095

Average rotatable bonds  3.523809524

Number of hydrogen bond donors  77

Number of hydrogen bond acceptors  72

X logP energy  -27.43839

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.