SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01259

Signal sequence   QPIDDTESQTTSVNLMADDTESAFATQTNSGGLDVVGLISMAEGK

Length  45

Organism  Artificial

UniProt ID  NA,

Motif  1..45



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01259.cif

Structure  SPKB01259.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4645.99624

Aliphatic index  71.55555556

Isoelectric point  3.375472527

Charge (pH=7)   -6.994752945

Topological polar surface area  2097.33

Aromaticity  0.022222222

Average rotatable bonds  3.466666667

Number of hydrogen bond donors  70

Number of hydrogen bond acceptors  73

X logP energy  -30.3212

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.