SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01245

Signal sequence   QPIDDTESQTTSVNLMADDTESAFATQTNSGGLDVVGLISMAREE

Length  45

Organism  Artificial

UniProt ID  NA,

Motif  1..45



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01245.cif

Structure  SPKB01245.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4746.07324

Aliphatic index  71.55555556

Isoelectric point  3.332655279

Charge (pH=7)   -7.9926861

Topological polar surface area  2170.51

Aromaticity  0.022222222

Average rotatable bonds  3.533333333

Number of hydrogen bond donors  73

Number of hydrogen bond acceptors  74

X logP energy  -30.95353

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.