SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01228

Signal sequence   QPIDDTESQTTSVNLMADDTESAFATQTNSGGLDVVGLISMAEK

Length  44

Organism  Artificial

UniProt ID  NA,

Motif  1..44



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01228.cif

Structure  SPKB01228.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4588.94434

Aliphatic index  73.18181818

Isoelectric point  3.375472527

Charge (pH=7)   -6.994752945

Topological polar surface area  2068.23

Aromaticity  0.022727273

Average rotatable bonds  3.5

Number of hydrogen bond donors  69

Number of hydrogen bond acceptors  72

X logP energy  -29.4374

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.