SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01227

Signal sequence   QPIDDTESQTTSVNLMADDTESAFATQTNSGGLDVVGLISMAEP

Length  44

Organism  Artificial

UniProt ID  NA,

Motif  1..44



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01227.cif

Structure  SPKB01227.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4557.88694

Aliphatic index  73.18181818

Isoelectric point  3.009694634

Charge (pH=7)   -7.994457912

Topological polar surface area  2033.42

Aromaticity  0.022727273

Average rotatable bonds  3.386363636

Number of hydrogen bond donors  67

Number of hydrogen bond acceptors  71

X logP energy  -29.0602

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.