SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01198

Signal sequence   SLALAAPVNTTTEDETAQIPAEAVIGYSDLEGDEDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLKREGEPK

Length  75

Organism  Artificial

UniProt ID  NA,

Motif  1..75



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01198.cif

Structure  SPKB01198.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7805.59284

Aliphatic index  95.06666667

Isoelectric point  3.746894096

Charge (pH=7)   -8.985992486

Topological polar surface area  3348.18

Aromaticity  0.04

Average rotatable bonds  3.426666667

Number of hydrogen bond donors  111

Number of hydrogen bond acceptors  113

X logP energy  -39.48463

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.