SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01197

Signal sequence   SLALAAPVNTTTEDETAQIPAEAVIGYSDLEGDEDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLKREEEPK

Length  75

Organism  Artificial

UniProt ID  NA,

Motif  1..75



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01197.cif

Structure  SPKB01197.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7877.65644

Aliphatic index  95.06666667

Isoelectric point  3.706400488

Charge (pH=7)   -9.984217364

Topological polar surface area  3385.48

Aromaticity  0.04

Average rotatable bonds  3.466666667

Number of hydrogen bond donors  112

Number of hydrogen bond acceptors  114

X logP energy  -39.25123

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.