SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01186

Signal sequence   SLALAAPVNTTTEDETAQIPAEAVIGYSDLEGDEDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLDKEEEPK

Length  75

Organism  Artificial

UniProt ID  NA,

Motif  1..75



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01186.cif

Structure  SPKB01186.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7836.55754

Aliphatic index  95.06666667

Isoelectric point  3.518861142

Charge (pH=7)   -11.98376757

Topological polar surface area  3360.88

Aromaticity  0.04

Average rotatable bonds  3.44

Number of hydrogen bond donors  110

Number of hydrogen bond acceptors  114

X logP energy  -39.0398

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.