SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01018

Signal sequence   SLALAAPVNTTTEDETAQIPAEAVIGYSDLEGDEDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLKGPK

Length  72

Organism  Artificial

UniProt ID  NA,

Motif  1..72



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01018.cif

Structure  SPKB01018.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7391.17434

Aliphatic index  99.02777778

Isoelectric point  3.683666434

Charge (pH=7)   -7.989539421

Topological polar surface area  3124.38

Aromaticity  0.041666667

Average rotatable bonds  3.347222222

Number of hydrogen bond donors  103

Number of hydrogen bond acceptors  107

X logP energy  -36.9319

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.