SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB01005

Signal sequence   SLALAAPVNTTTEDETAQIPAEAVIGYSDLEGDEDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLKRGP

Length  72

Organism  Artificial

UniProt ID  NA,

Motif  1..72



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB01005.cif

Structure  SPKB01005.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7419.18774

Aliphatic index  99.02777778

Isoelectric point  3.683666447

Charge (pH=7)   -7.989247698

Topological polar surface area  3160.26

Aromaticity  0.041666667

Average rotatable bonds  3.347222222

Number of hydrogen bond donors  105

Number of hydrogen bond acceptors  107

X logP energy  -37.79763

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.