SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00983

Signal sequence   SLALAAPVNTTTEDETAQIPAEAVIGYSDLEGDEDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLDREP

Length  72

Organism  Artificial

UniProt ID  NA,

Motif  1..72



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00983.cif

Structure  SPKB00983.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7478.16584

Aliphatic index  99.02777778

Isoelectric point  3.415448252

Charge (pH=7)   -10.98673106

Topological polar surface area  3208.84

Aromaticity  0.041666667

Average rotatable bonds  3.361111111

Number of hydrogen bond donors  106

Number of hydrogen bond acceptors  108

X logP energy  -38.21853

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.