SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00966

Signal sequence   SLALAAPVNTTTEDETAQIPAEAVIGYSDLEGDEDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLGEP

Length  71

Organism  Artificial

UniProt ID  NA,

Motif  1..71



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00966.cif

Structure  SPKB00966.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7263.94164

Aliphatic index  100.4225352

Isoelectric point  3.242031182

Charge (pH=7)   -10.98717423

Topological polar surface area  3080.54

Aromaticity  0.042253521

Average rotatable bonds  3.295774648

Number of hydrogen bond donors  101

Number of hydrogen bond acceptors  105

X logP energy  -36.8099

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.