SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00949

Signal sequence   SLALAAPVNTTTEDETAQIPAEAVIGYSDLEGDEDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLKPK

Length  71

Organism  Artificial

UniProt ID  NA,

Motif  1..71



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00949.cif

Structure  SPKB00949.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7334.12244

Aliphatic index  100.4225352

Isoelectric point  3.683666434

Charge (pH=7)   -7.989539421

Topological polar surface area  3095.28

Aromaticity  0.042253521

Average rotatable bonds  3.366197183

Number of hydrogen bond donors  102

Number of hydrogen bond acceptors  106

X logP energy  -36.0481

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.