SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00888

Signal sequence   MKFKLTLLAALLALAALVLAAS

Length  22

Organism  Artificial

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00888.cif

Structure  SPKB00888.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2242.87534

Aliphatic index  186.8181818

Isoelectric point  10.80537956

Charge (pH=7)   1.997394232

Topological polar surface area  766.92

Aromaticity  0.045454545

Average rotatable bonds  3.409090909

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  28

X logP energy  -1.6299

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.