SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00885

Signal sequence   MKLKTVRSAVLSSLFASQVLG

Length  21

Organism  Artificial

UniProt ID  NA,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00885.cif

Structure  SPKB00885.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2235.71364

Aliphatic index  125.2380952

Isoelectric point  11.82305527

Charge (pH=7)   2.99739092

Topological polar surface area  903.5

Aromaticity  0.047619048

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  32

X logP energy  -8.94953

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.