SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00884

Signal sequence   MKLSSLLLALLLALASLALAAPK

Length  23

Organism  Artificial

UniProt ID  NA,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00884.cif

Structure  SPKB00884.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2321.97414

Aliphatic index  195.6521739

Isoelectric point  10.80537956

Charge (pH=7)   1.997394232

Topological polar surface area  807.46

Aromaticity  0

Average rotatable bonds  3.391304348

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  30

X logP energy  -2.8615

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.