SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00872

Signal sequence   MKLSTLLLTLLLLLLALVLAS

Length  21

Organism  Artificial

UniProt ID  NA,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00872.cif

Structure  SPKB00872.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2252.95154

Aliphatic index  246.1904762

Isoelectric point  9.700002532

Charge (pH=7)   0.997689266

Topological polar surface area  752.26

Aromaticity  0

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  28

X logP energy  -0.0284

Hydropathy 



Literature Information


Title  SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS PROTEINS IN YEAST

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240174722A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.