SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00861

Signal sequence   MKLISVGIVTTLLTLASC

Length  18

Organism  Komagataella phaffii

UniProt ID  C4QVN9,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00861.cif

Structure  SPKB00861.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1863.34474

Aliphatic index  167.7777778

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  685.19

Aromaticity  0

Average rotatable bonds  3.444444444

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  27

X logP energy  -5.1813

Hydropathy 



Literature Information


Title  SIGNAL PEPTIDES FOR INCREASED PROTEIN SECRETION

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240141363A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.